Gergely Orban PDF Print E-mail
I graduated with an MSc in Human and Neuro-biology from Eotvos Lorand University (Budapest, Hungary) in 2005. I remained in Budapest for my PhD studies as a student in the Laboratory of Proteomics, led by Prof. Gabor Juhasz. During my PhD, I examined the influence of different beta-amyloid compounds on the excitability of hippocampal pyramidal cells by recording population spikes and EPSPs in awake and freely moving rats.
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I moved to Cardiff in 2008 to be part of Prof. Crunelli’s group. Here, I joined an on-going project aiming at characterizing the role of the tonic GABA-A current in typical absence seizures using EEG recordings and microdialysis in vivo. At present, my research here focuses on the role of T-type calcium channels on thalamo-cortical synchronization processes in models of absence epilepsy and during sleep in vivo. I use in vivo methods, such as local administration of compounds by reverse microdialysis, EEG, local field potentials, multi-unit and neuronal ensemble recordings (with silicone probes and tetrodes) in the ventrobasal thalamus and somatosensory cortex in awake behaving animals.
 
 
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The dynamic interplay of
cortical and thalamic
oscillators underlies
Slow Sleep Oscillations
NATURE NEUROSCIENCE
January 2010
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Enhanced tonic GABA-A
inhibition is required
for Absence Epilepsy
NATURE MEDICINE
December 2009
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Temporal framing of
tonic firing by thalamic
interneurons during
the Alpha Rhythm
NEURON
September 2009
 
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